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Biol Reprod 2022;106(6):1218-1231
SURMOUNT-1 (Jastreboff 2022, NEJM) reported up to 20.9 percent average weight loss with tirzepatide versus 14.9 percent with semaglutide in STEP 1 (Wilding 2021, NEJM)
As it stands, weight loss surgery is by far the most effective way to treat obesity today
Daily weight (looking at weekly averages, not daily fluctuations), weekly photos, and body measurements provide objective data that cuts through the subjective experience of "I do not feel like it is working." Many people are visibly losing fat and improving body composition even when the scale is temporarily stalled
Phase 2 trial - Lancet, 2023 Liver fat (fatty-liver disease) Liver fat measured by MRI in people with fatty-liver disease - the trial behind the -82.4% figure
While most of us will get what we need from the diet we eat, B12 can be particularly difficult for those who dont or cant eat certain foods such as meat, shellfish, eggs and dairy
